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Chemical structure of SB 612111 hydrochloride | 371980-98-2
CAS: 371980-98-2
SKU: S2420
SB 612111 hydrochloride | SKU: S2420
Synonyms:(5S,7S)-7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol hydrochloride
Chemical structure of SB 612111 hydrochloride | 371980-98-2
SB-612111 hydrochloride (CAS 371980-98-2) is a potent, selective small-molecule antagonist of the nociceptin receptor (ORL-1), supplied by Sarchem Labs as a high-purity research reagent for pain and receptor-signaling studies. It binds ORL-1 with high affinity while showing very low affinity for the classic opioid receptors, giving researchers a selective pharmacological tool rather than a broad-spectrum opioid-pathway modulator. Sarchem Labs supplies this compound with a Certificate of Analysis and Safety Data Sheet for every lot, supporting reproducible use in receptor-binding and behavioral pharmacology research. It is used almost exclusively in academic and pharmaceutical research settings studying nociceptin/ORL-1 signaling, pain pathways, and opioid-receptor pharmacology — not as a bulk industrial or consumer chemical.
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Specifications

ColorWhite to beige
Physical FormPowder
Molecular Weight454.86 g/mol
SMILES String`Clc1c(c(ccc1)Cl)C2CCN(CC2)C[C@@H]3C[C@@H](c4c(c(ccc4)C)CC3)O.Cl`
Assay≥98% (HPLC)
SolubilityDMSO: 15 mg/mL (clear)
CAS Number371980-98-2
Storage Temperature−20 °C, desiccated
Empirical FormulaC24H29Cl2NO · HCl
NACRESNA.77
UNSPSC Code12352200
Quality Segment100
InChI`1S/C24H29Cl2NO.ClH/c1-16-4-2-5-20-19(16)9-8-17(14-23(20)28)15-27-12-10-18(11-13-27)24-21(25)6-3-7-22(24)26;/h2-7,17-18,23,28H,8-15H2,1H3;1H/t17-,23-;/m0./s1`
InChI KeyRGHPCLZJAFCTIK-DQFHVVJASA-N
ApplicationsPharmacological research into nociceptin/orphanin FQ (N/OFQ) receptor (ORL-1) signaling

Applications

Pharmacological research into nociceptin/orphanin FQ (N/OFQ) receptor (ORL-1) signaling
Selective ORL-1 antagonist tool compound for distinguishing nociceptin-mediated effects from classic opioid-receptor effects
Studies of nociceptin-induced thermal hyperalgesia and its blockade
Investigation of anti-morphine effects mediated by the nociceptin/ORL-1 system
Receptor classification and signal transduction reference research (featured in the Handbook of Receptor Classification and Signal Transduction)

Product Description

What is SB-612111 Hydrochloride?

SB-612111 hydrochloride is a synthetic small-molecule antagonist that selectively blocks the nociceptin receptor, also called ORL-1 (opioid receptor-like 1). It binds ORL-1 with high affinity (Ki = 0.33 nM) while showing very low affinity for the classic mu, delta, and kappa opioid receptors, which makes it a pharmacologically clean tool for isolating nociceptin-specific effects from general opioid-receptor activity. Structurally, it is the hydrochloride salt of a benzocycloheptene-piperidine scaffold, supplied as a white-to-beige powder that should be stored desiccated at −20 °C to preserve potency.

Uses of SB-612111 Hydrochloride

Researchers use SB-612111 hydrochloride primarily to probe the biological role of the nociceptin/ORL-1 signaling system, since blocking this receptor lets scientists isolate its contribution to a given physiological response. Published pharmacology work has relied on the compound to show that shutting down ORL-1 signaling reverses nociceptin’s dampening effect on morphine activity and prevents the heightened pain sensitivity (thermal hyperalgesia) that nociceptin exposure otherwise triggers — evidence that has shaped how researchers think about the crosstalk between the nociceptin system and classic opioid analgesia. Because of its well-characterized receptor selectivity, it is also referenced as a standard tool compound in receptor classification literature, including the Handbook of Receptor Classification and Signal Transduction.

Safety Information

  • Storage Class: 11 – Combustible Solids
  • Water Hazard Class (WGK): 3
  • Storage Conditions: Store desiccated at −20 °C
  • Flash Point: Not applicable

No GHS pictograms, signal word, or hazard statement (H-code) data were listed in the reference data reviewed. As a bioactive pharmacological research compound, standard laboratory precautions (gloves, eye protection, avoid inhalation of powder) are recommended regardless — consult the current SDS for complete hazard classification before handling.

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FAQs: SB 612111 hydrochloride

SB-612111 hydrochloride is used in pharmacology research as a selective antagonist of the nociceptin receptor (ORL-1), helping researchers study nociceptin signaling, pain pathways, and its interaction with the opioid-receptor system.

Yes — it binds ORL-1 with high affinity (Ki = 0.33 nM) while showing very low affinity for classic opioid receptors, making it a selective research tool rather than a broad opioid-pathway modulator.

It should be stored desiccated at −20 °C to preserve compound stability and potency between uses, consistent with standard handling for sensitive research-grade small molecules.

No — Sarchem supplies this compound as a research reagent for laboratory pharmacology studies, not as a pharmaceutical-grade or clinical-use material; it should not be administered to humans or animals outside of a controlled, ethically approved research protocol.

Each lot ships with a Certificate of Analysis and Safety Data Sheet, allowing researchers to confirm identity, purity (≥98% by HPLC), and handling requirements before use in the lab.