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(S)-1-Boc-2-cyanopiperidine
CAS: 228244-04-0
SKU: S2906
(S)-1-Boc-2-cyanopiperidine | SKU: S2906
Synonyms: tert-Butyl (2S)-2-cyano-1-pyrrolidinecarboxylate
(S)-1-Boc-2-cyanopiperidine
(S)-tert-Butyl 2-cyanopyrrolidine-1-carboxylate is a Boc-protected chiral pyrrolidine nitrile that Sarchem Labs supplies for pharmaceutical intermediate manufacturing. Every lot ships with a Certificate of Analysis and Safety Data Sheet.
Request Quote — S2906

Specifications

AppearanceN/A
Content of ZincN/A
Boiling PointN / A
Melting Point33°C
Vapor PressureN/A
% Volatile by WeightN/A
Solubility in WaterN/A
DensityN/A
pH of Liquid, Typical (10% soln)N/A
Specific Gravity ApproxN/A
OdorN/A
pHN/A
Flash PointN/A
Ignition temperatureN/A
Lower exposure limitN/A
Upper exposure limitN/A
ColorWhite-Yellow
Linear FormulaC10H16O2N2
Formula Weight196.25
Physical FormCrystal-lump at 20°C
Chemical Name or Material(S)-1-(tert-Butoxycarbonyl)-2-cyanopyrrolidine
Molecular Weight196.25 g/mol
CAS Number228244-04-0
ApplicationsDPP-4 inhibitor drug manufacturing — Boc-2-cyanopyrrolidine building blocks of this type are the standard synthetic precursors to nitrile-based dipeptidyl peptidase-4 (DPP-4) inhibitors, a major class of type 2 diabetes drugs (e.g., vildagliptin-class chemistry)

Applications

DPP-4 inhibitor drug manufacturing — Boc-2-cyanopyrrolidine building blocks of this type are the standard synthetic precursors to nitrile-based dipeptidyl peptidase-4 (DPP-4) inhibitors, a major class of type 2 diabetes drugs (e.g., vildagliptin-class chemistry)
Pharmaceutical intermediate manufacturing (chiral pyrrolidine building block)

Product Description

What is (S)-1-Boc-2-cyanopyrrolidine?

This compound is a pyrrolidine ring bearing a Boc (tert-butoxycarbonyl) protecting group and a nitrile substituent, with defined (S)-stereochemistry. The nitrile-pyrrolidine motif, once deprotected, is a hallmark structural feature of nitrile-class DPP-4 inhibitor drugs used to treat type 2 diabetes.

Uses of (S)-1-Boc-2-cyanopyrrolidine

This compound is used as a chiral building block in pharmaceutical manufacturing, particularly for constructing nitrile-based DPP-4 inhibitor active pharmaceutical ingredients after Boc deprotection.

Safety Information

PPE: Standard laboratory precautions — gloves, eyeshields, dust mask

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FAQs: (S)-1-Boc-2-cyanopiperidine

Mainly as a chiral building block in pharmaceutical manufacturing, particularly nitrile-class DPP-4 inhibitor (type 2 diabetes drug) synthesis.

It's a pyrrolidine (5-membered ring) — Sarchem's page title currently says "piperidine," but the CAS number and all published data confirm the pyrrolidine structure. See Critical Finding #7.

Yes, for every lot (SKU S2906).