| Boiling Point | 83°C (lit.) |
| Density | 0.86 g/mL at 25°C (lit.) |
| Color | Yellow |
| Linear Formula | HC≡CCH2NH2 |
| Formula Weight | 55.08 |
| Physical Form | Clear liquid |
| Chemical Name or Material | Propargylamine |
| UN Number | UN3286 |
| Molecular Weight | 55.08 g/mol |
| SMILES String | NCC#C |
| Refractive Index | n20/D 1.449 (lit.) |
| Total Trace Metal Impurities | ≤2.5% water |
| CAS Number | 2450-71-7 |
| Storage Temperature | 2–8°C |
| EC Number | 219-513-8 |
| NACRES | NA.22 |
| PubChem Substance ID | 24898592 |
| UNSPSC Code | 12352100 |
| MDL Number | MFCD00008198 |
| InChI | 1S/C3H5N/c1-2-3-4/h1H,3-4H2 |
| InChI Key | JKANAVGODYYCQF-UHFFFAOYSA-N |
| Beilstein/REAXYS Number | 773681 |
| Quality Level | 200 |
| Reference Assay | 98% |
Propargylamine is the smallest propargylic amine, combining a terminal alkyne group with a primary amine on adjacent carbons. That dual functionality makes it a versatile building block: the amine can be acylated or alkylated in standard synthetic steps, while the alkyne is a natural handle for copper-catalyzed azide-alkyne click chemistry, making the molecule useful for constructing more complex, functionalized targets from a very small starting material.
In pharmaceutical synthesis, propargylamine derivatives are studied as multi-target-directed ligands, including research into monoamine oxidase inhibitors relevant to neurodegenerative disease research. Its terminal alkyne makes it a standard reagent in 1,3-dipolar cycloaddition (click chemistry) for constructing macrocycles and other complex architectures, and it’s used in site-specific bioconjugation chemistry via transglutaminase-catalyzed propargylation of proteins. It also serves as a building block in broader agrochemical and specialty-chemical synthesis.
CRITICAL: This compound is classified H310 — Fatal in contact with skin. Sarchem’s live page currently has zero safety information for this product.
