Pinacidil Monohydrate is a research-grade chemical compound and the monohydrate form of pinacidil, a cyanoguanidine derivative known for its activity as a potassium channel opener. It is widely used in laboratory and pharmaceutical research to study ATP-sensitive potassium (KATP) channels, membrane hyperpolarisation, and related cellular and vascular mechanisms.
| Appearance | White to off-white solid / powder |
| Melting Point | 164 – 165 °C |
| pH of Liquid, Typical (10% soln) | Not typically specified for solid research chemical (not applicable) |
| Specific Gravity Approx | Not routinely reported for powders |
| Odor | Characteristic (solid) |
| Color | White to off-white |
| Linear Formula | C₁₃H₁₉N₅ · H₂O |
| IUPAC Name | 1-cyano-2-(3,3-dimethylbutan-2-yl)-3-pyridin-4-ylguanidine; hydrate |
| Formula Weight | ~263.34 g/mol |
| percent purity | ≥ 98 % |
| Physical Form | Powder / crystalline solid |
| Content / Assay Percent Range | ≥ 98 % (HPLC) |
Classification of the substance or mixture
GHS Label elements, including precautionary statements
Hazards not otherwise classified (HNOC) or not covered by GHS
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS). For the full text of the H-Statements mentioned in this Section, see Section 16.
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Pinacidil monohydrate is a potassium channel opener used primarily in research focused on cardiovascular health. It helps relax vascular smooth muscles, aiding in blood pressure regulation studies.
Pinacidil monohydrate is valued for its vasodilatory effects, making it essential in hypertension and cardiac pharmacology research. It helps investigate mechanisms of vascular tone and blood flow improvement.
Pinacidil monohydrate activates ATP-sensitive potassium channels in smooth muscle cells, leading to hyperpolarisation and vasodilation. This mechanism is key in understanding blood pressure modulation in experimental models.
Yes, pinacidil monohydrate is often used as a reference compound in the development of novel vasodilators. Its well-characterised mechanism provides a foundation for cardiovascular drug screening and testing.
Pinacidil monohydrate typically appears as a white to off-white powder, with good solubility in organic solvents. It remains stable under recommended storage conditions, ensuring consistent research results.
