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Chemical structure of N,N-Diisopropylethylamine | 7087-68-5
CAS: 7087-68-5
SKU: S1437
N,N-Diisopropylethylamine | SKU: S1437
Synonyms: DIPEA; Hünig’s Base; Diisopropylethylamine
Chemical structure of N,N-Diisopropylethylamine | 7087-68-5
N,N-Diisopropylethylamine (DIPEA, commonly known as Hünig’s Base) is a sterically hindered, non-nucleophilic organic base that Sarchem Labs supplies as a clear liquid for peptide-synthesis and pharmaceutical manufacturing. It’s one of the most widely used bases in organic synthesis, prized for driving reactions without competing as a nucleophile. Every lot ships with a Certificate of Analysis and Safety Data Sheet.
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Specifications

Boiling Point127°C (per Sarchem's existing published data)
Melting Point−45°C (per Sarchem's existing published data)
ColorYellow
Formula Weight129.25
Physical FormClear liquid
Chemical Name or MaterialN,N-Diisopropylethylamine
UN NumberUN2733
Molecular Weight129.25 g/mol
CAS Number7087-68-5
ApplicationsPeptide-synthesis manufacturing (non-nucleophilic base for coupling reactions)

Applications

Peptide-synthesis manufacturing (non-nucleophilic base for coupling reactions)
Pharmaceutical intermediate manufacturing (acid scavenger in acylation, alkylation reactions)
Organic synthesis base for palladium-catalyzed cross-coupling chemistry

Product Description

What is DIPEA?

DIPEA is a tertiary amine whose bulky diisopropyl substituents create significant steric hindrance around the nitrogen atom. That steric bulk prevents the base from acting as an effective nucleophile itself, while it remains fully capable of deprotonating acids and scavenging HCl or other acidic byproducts — making it the base of choice whenever a reaction needs basicity without unwanted nucleophilic side reactions.

Uses of DIPEA

DIPEA is a workhorse base throughout peptide-synthesis manufacturing, used in carbodiimide- and uronium-based coupling reactions (alongside reagents like HOBt, HATU, and CDI featured elsewhere in this batch). It’s equally standard in pharmaceutical intermediate manufacturing as an acid scavenger for acylation and alkylation reactions, and in palladium-catalyzed cross-coupling chemistry as a mild, non-nucleophilic base.

Safety Information

  • Signal Word: Danger | Hazard Statements: H225 (Highly flammable liquid and vapor), H302 (Harmful if swallowed), H318 (Causes serious eye damage), H331 (Toxic if inhaled), H335 (May cause respiratory irritation)
  • Hazard Classification: Flammable Liquid 2, Acute Tox. 4 Oral, Acute Tox. 3 Inhalation, Eye Damage 1, STOT SE 3
  • PPE: Faceshields, chemical-resistant gloves, goggles, respirator — fume hood recommended given the inhalation-toxicity classification

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FAQs: N,N-Diisopropylethylamine

Mainly as a non-nucleophilic base in peptide-synthesis coupling reactions, an acid scavenger in pharmaceutical intermediate manufacturing, and a base in palladium-catalyzed cross-coupling chemistry.

Its bulky diisopropyl groups sterically block the nitrogen from acting as an effective nucleophile, so it can deprotonate acids/scavenge acidic byproducts without itself reacting as a competing nucleophile in the reaction.

Yes — it's classified Danger, highly flammable, toxic if inhaled, and causes serious eye damage; full PPE including respiratory protection and a fume hood are recommended.

Yes, for every lot (SKU S1437).