| Boiling Point | 145–148°C/1013 hPa |
| Density | 0.81 g/cm³ at 20°C |
| Color | Yellow |
| Linear Formula | (CH3)2CHN=C=NCH(CH3)2 |
| Formula Weight | 126.20 |
| Physical Form | Liquid |
| Chemical Name or Material | N,N′-Diisopropylcarbodiimide |
| UN Number | 2929 |
| Molecular Weight | 126.20 g/mol |
| SMILES String | N(=C=NC(C)C)C(C)C |
| Assay | ≥99.0% (GC) |
| CAS Number | 693-13-0 |
| Storage Temperature | 2–30°C |
| NACRES | NA.22 |
| UNSPSC Code | 12352111 |
| MDL Number | MFCD00065689 |
| InChIKey | BDNKZNFMNDZQMI-UHFFFAOYSA-N |
| Applications | Peptide-synthesis manufacturing (carbodiimide coupling agent, alternative to DCC with easier-to-remove urea byproduct) |
DIC is a liquid carbodiimide containing the reactive RN=C=NR functional group. It activates carboxylic acids toward coupling with amines or alcohols, making it a standard reagent for forming amide and ester bonds — most notably in solid-phase peptide synthesis, where its liquid form and soluble urea byproduct make it easier to work with than solid alternatives like DCC.
DIC is manufactured into peptide-synthesis workflows as the primary coupling reagent (often paired with HOBt or Oxyma to suppress racemization), and used more broadly in pharmaceutical intermediate manufacturing anywhere an ester or amide bond needs to be formed from a carboxylic acid.
