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CAS: 19752928
SKU: S2917
Nitazoxanide | SKU: S2917
Synonyms: NTZ; 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide; Alinia (brand reference only)
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Nitazoxanide is a nitrothiazolyl-salicylamide compound that Sarchem Labs supplies as a bulk research- and technical-grade chemical for pharmaceutical R&D and antiparasitic/antiviral research. It’s the active ingredient in an FDA-approved broad-spectrum antiprotozoal medication (originated by Romark) and has drawn substantial additional research interest as a broad-spectrum antiviral candidate. Sarchem Labs backs every lot with a Certificate of Analysis and Safety Data Sheet. This listing is a bulk research chemical, not a finished, FDA-approved drug product.
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Specifications

AppearanceN/A
Content of ZincN/A
Boiling PointN / A
Melting PointN/A
Vapor PressureN/A
% Volatile by WeightN/A
Solubility in WaterN/A
DensityN/A
pH of Liquid, Typical (10% soln)N/A
Specific Gravity ApproxN/A
OdorN/A
pHN/A
Flash PointN/A
Ignition temperatureN/A
Lower exposure limitN/A
Upper exposure limitN/A
Physical FormPowder
Chemical Name or MaterialNitazoxanide
Molecular Weight307.28 g/mol
SMILES StringCC(=O)Oc1ccccc1C(=O)Nc2ncc(s2)[N+]([O-])=O
CAS Number55981-09-4
Storage Temperature2–8°C
EC Number259-931-8
Empirical FormulaC12H9N3O5S
NACRESNA.77
PubChem Substance ID329818424
UNSPSC Code12352200
MDL NumberMFCD00416599
InChI1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)
InChI KeyYQNQNVDNTFHQSW-UHFFFAOYSA-N
Quality Level100
Reference Assay≥98% (HPLC)
OriginatorRomark
ApplicationsPharmaceutical R&D reference standard for antiparasitic mechanism research

Applications

Pharmaceutical R&D reference standard for antiparasitic mechanism research
Broad-spectrum antiviral repurposing research (actively studied against multiple viral targets)
Pyruvate-ferredoxin oxidoreductase (PFOR) inhibition research
Analytical method development and QC reference material

Product Description

What is Nitazoxanide?

Nitazoxanide is a synthetic thiazolide compound, structurally related to niclosamide, combining a nitro-substituted thiazole ring with a salicylamide (acetylated hydroxybenzamide) group. It’s an FDA-approved (2002) broad-spectrum antiprotozoal medication effective against a range of intestinal parasites, acting as an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR) — a mechanism distinct from most other antiparasitic drugs, which has made it a widely studied repurposing candidate for antimicrobial and antiviral research beyond its original indication.

Uses of Nitazoxanide

Pharmaceutical R&D teams use bulk-grade nitazoxanide like Sarchem’s for analytical reference work and process chemistry related to its antiparasitic/PFOR-inhibition mechanism. It’s also a frequently cited compound in broad-spectrum antiviral repurposing research — studied against chikungunya virus, Japanese encephalitis virus, and human cytomegalovirus, among others — as well as in antimicrobial research against both replicating and non-replicating mycobacteria.

Safety Information

*Sigma’s reference listing for this compound carries no GHS hazard pictogram or hazard statement on file.*

  • Storage Class: 11 – Combustible Solids
  • Storage Temperature: 2–8°C (refrigerated)
  • PPE: Standard laboratory precautions — gloves, eyeshields, dust mask recommended as routine good practice given its pharmacological activity

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FAQs: Nitazoxanide

As an analytical reference standard for antiparasitic/PFOR-inhibition mechanism research, and as a subject of ongoing broad-spectrum antiviral and antimicrobial repurposing research.

Chemically the same molecule, but Sarchem supplies it as a bulk research/technical-grade chemical, not the finished, FDA-approved Alinia drug product, which requires separately sourced, regulatory-approved material.

55981-09-4. (Sarchem's live page currently shows an invalid value in the CAS field — see the bug report at the top of this document.)

C12H9N3O5S, molecular weight 307.28 g/mol.

Yes, for every lot (SKU S2917).