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Chemical structure of Niacinamide | 98-92-0
CAS: 98-92-0
SKU: S2725
Niacinamide | SKU: S2725
Synonyms: Nicotinamide; 3-Pyridinecarboxamide; Vitamin PP; Niacinamide
Chemical structure of Niacinamide | 98-92-0
Niacinamide, also known as nicotinamide, is the amide form of vitamin B3 that Sarchem Labs supplies as a white crystalline powder for cosmetic, nutraceutical, pharmaceutical, and food-fortification applications. Unlike niacin (nicotinic acid), the amide form doesn’t cause the characteristic flushing reaction, which has made it the preferred B3 form in both dietary supplements and skincare formulations. Every lot ships with a Certificate of Analysis and Safety Data Sheet.
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Specifications

Melting Point128–131°C (lit.)
pH6.0 to 7.5 (50g/L H2O soln.)
ColorWhite
Formula Weight122.13
Physical FormPowder
Chemical Name or MaterialNicotinamide
Molecular Weight122.12 g/mol
SMILES StringNC(=O)c1cccnc1
CAS Number98-92-0
EC Number202-713-4
Empirical FormulaC6H6N2O
NACRESNA.77
PubChem Substance ID24897638
UNSPSC Code12352200
MDL NumberMFCD00006395
InChI1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
InChI KeyDFPAKSUCGFBDDF-UHFFFAOYSA-N
Beilstein/REAXYS Number383619
InChIKeyDFPAKSUCGFBDDF-UHFFFAOYSA-N
Quality Level200
Reference Assay≥98% (HPLC)

Applications

Dietary supplement and vitamin-fortification raw material (vitamin B3/PP source)
Cosmetic skincare formulation (skin-barrier support, brightening, anti-aging products)
Pharmaceutical formulation (pellagra treatment, niacin-deficiency therapies)
Food fortification and animal feed additive
Cell-analysis and enzyme-cofactor research (NAD+/NADP+ pathway studies)

Product Description

What is Niacinamide?

Niacinamide is the amide form of niacin (vitamin B3/nicotinic acid) — a small pyridine-ring molecule that serves as a precursor to NAD+ and NADP+, two coenzymes central to cellular energy metabolism. Unlike its parent acid, niacinamide doesn’t trigger the flushing response some people experience with nicotinic acid, which is why it’s the form most commonly chosen for supplement and topical formulations.

Uses of Niacinamide

As a supplement ingredient, niacinamide fortifies multivitamins and targeted B3 products, and it’s a standard raw material in pharmaceutical formulations addressing niacin deficiency. In cosmetic chemistry, it’s widely formulated into skincare products for its skin-barrier and brightening properties. It also serves as a food and animal-feed fortification ingredient, and as a research reagent in cell-analysis work involving NAD+/NADP+ cofactor pathways.

Safety Information

  • Signal Word: Warning | Hazard Statement: H319 (Serious eye irritation)
  • Storage Class: 11 – Combustible Solids | Flash Point: 150°C (closed cup)
  • PPE: Dust mask (type N95), eyeshields, gloves

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FAQs: Niacinamide

Mainly as a vitamin B3 supplement/fortification ingredient and as a widely used cosmetic skincare active; also used in pharmaceutical formulations for niacin deficiency.

No — niacin (nicotinic acid) and niacinamide (nicotinamide) are both forms of vitamin B3, but niacinamide is the amide form and does not cause the flushing reaction associated with niacin.

98-92-0, C6H6N2O, molecular weight 122.12 g/mol.

It's classified as a mild eye irritant (H319); standard PPE (goggles, gloves) is sufficient for typical handling.

Yes, for every lot (SKU S2725).