CAS: 2216-51-5
SKU: S3268
Menthol Crystals, USP | SKU: S3268
Synonyms: L-Menthol; Levomenthol; Hexahydrothymol; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol
Menthol Crystals, USP is the pharmacopeial-grade form of L-menthol that Sarchem Labs supplies as white crystalline solid for pharmaceutical, flavor/fragrance, and cosmetic formulation. Naturally derived from mint plants (and also produced synthetically), menthol’s distinctive cooling sensation on skin and mucous membranes makes it one of the most widely used natural actives in over-the-counter and personal-care products. Every lot ships with a Certificate of Analysis and Safety Data Sheet.

Specifications

Boiling Point216°C
Melting Point41–44°C
ColorWhite
Linear FormulaC10H19OH
Formula Weight156.27
Physical FormSolid
Chemical Name or Material(-)-Menthol
Molecular Weight156.27 g/mol
SMILES StringCC(C)[C@@H]1CC[C@@H](C)C[C@H]1O
CAS Number2216-51-5
EC Number218-690-9
NACRESNA.22
PubChem Substance ID57647522
UNSPSC Code12352001
MDL NumberMFCD00062979
InChI1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1
InChI KeyNOOLISFMXDJSKH-KXUCPTDWSA-N
Beilstein/REAXYS Number1902293
Quality Level200
Reference Assay98.0–102.0%
Optical Activity[α]20/D −48 to −51° (c=10% in ethanol)
Compendial ComplianceMeets Ph. Eur., BP, USP analytical specification
ApplicationsOTC pharmaceutical formulation (topical analgesics, cough drops, decongestants, chest rubs)

Applications

OTC pharmaceutical formulation (topical analgesics, cough drops, decongestants, chest rubs)
Flavor and fragrance industry (mint flavoring, tobacco flavoring)
Cosmetic formulation (cooling agent in skincare and personal-care products)
Oral-care product formulation (toothpaste, mouthwash)

Product Description

What is Menthol?

Menthol is a cyclic monoterpene alcohol best known for the cooling sensation it produces on skin and mucous membranes — a physiological effect caused by its activation of TRPM8 cold-sensing receptors rather than any actual temperature change. Sarchem’s material meets USP (along with Ph. Eur. and BP) compendial standards, the pharmacopeial specification pharmaceutical manufacturers rely on for consistent identity and purity.

Uses of Menthol

Menthol’s cooling and mild local-anesthetic properties make it a workhorse active in over-the-counter pharmaceutical products, including topical analgesic rubs, cough drops, and nasal decongestant formulations. It’s equally important in the flavor and fragrance industry as a mint-flavoring agent, and it’s a common cosmetic and oral-care ingredient wherever a cooling sensory effect is desired.

Safety Information

  • Signal Word: Warning | Hazard Statements: H315 (Skin irritation), H319 (Serious eye irritation)
  • Storage Class: 11 – Combustible Solids | Flash Point: 94°C (closed cup)
  • PPE: Dust mask (type N95), eyeshields, gloves

Related Products

FAQs: Menthol Crystals, USP

Mainly in OTC pharmaceutical products (topical analgesics, cough drops, decongestants), flavor/fragrance formulation, and cosmetic/oral-care products, wherever a cooling sensory effect is needed.

It activates TRPM8 cold-sensing receptors in the skin and mucous membranes, triggering a genuine cooling sensation without any actual drop in temperature.

USP indicates the material meets United States Pharmacopeia compendial standards for identity, purity, and quality — the specification pharmaceutical manufacturers require for OTC and drug formulation use.

2216-51-5, C10H19OH, molecular weight 156.27 g/mol.

Yes, for every lot (SKU S3268).