Quote
Chemical structure of HATU | 148893-10-1
CAS: 148893-10-1
SKU: S3421
HATU | SKU: S3421
Synonyms: 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate; N-[(Dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide
Chemical structure of HATU | 148893-10-1
HATU is a uronium-type coupling reagent that Sarchem Labs supplies as a white-yellow crystalline solid for peptide synthesis and amide bond formation chemistry. It’s one of the most widely used and highly efficient peptide-coupling reagents in solid-phase and solution-phase synthesis, valued for fast, high-yielding activation of carboxylic acids. Every lot ships with a Certificate of Analysis and Safety Data Sheet.
Request Quote — S3421

Specifications

Melting Point183–185°C (lit.)
ColorWhite-Yellow
Formula Weight380.24
Physical FormCrystal-powder
Chemical Name or MaterialHATU
Molecular Weight380.23 g/mol
SMILES StringF[P-](F)(F)(F)(F)F.CN(C)[C+](N(C)C)n1n[n+]([O-])c2ncccc12
CAS Number148893-10-1
Storage Temperature2–8°C
Empirical FormulaC10H15F6N6OP
NACRESNA.22
PubChem Substance ID24868183
UNSPSC Code12352302
MDL NumberMFCD27957364
InChI1S/C10H15N6O.F6P/c1-13(2)10(14(3)4)15-8-6-5-7-11-9(8)16(17)12-15;1-7(2,3,4,5)6/h5-7H,1-4H3;/q+1;-1
InChI KeyFKBFHOSFPRWJNV-UHFFFAOYSA-N
Quality Level200
Reference Assay97%
ApplicationsPeptide coupling reagent for solid-phase and solution-phase synthesis

Applications

Peptide coupling reagent for solid-phase and solution-phase synthesis
Amide bond formation reactions
N-arylsulfonamide-linked peptide synthesis
Selective acylation and catalytic coupling chemistry

Product Description

What is HATU?

HATU is a uronium-based coupling reagent built around an azabenzotriazole core, designed to rapidly activate carboxylic acids for amide bond formation. That activation chemistry underlies its central role in modern peptide synthesis, where fast, clean amide coupling with minimal racemization is essential for building peptide chains efficiently.

Uses of HATU

HATU’s primary use is as a peptide coupling reagent in solid-phase and solution-phase peptide synthesis, forming amide bonds between amino acid residues with high efficiency. It’s also used for constructing N-arylsulfonamide-linked peptides, as a catalyst for selective acylation reactions, and in the synthesis of various pharmaceutically relevant intermediates, including kinase-inhibitor building blocks.

Safety Information

Sigma Aldrich’s GHS classification includes a respiratory sensitizer warning — important for repeated-handling scenarios.

  • Signal Word: Danger | Hazard Statements: H317 (May cause an allergic skin reaction), H334 (May cause allergy or asthma symptoms or breathing difficulties if inhaled)
  • Storage Class: 4.1A – Other explosive hazardous materials
  • PPE: Dust mask (type N95), eyeshields, gloves — minimize inhalation exposure given the respiratory sensitizer classification

Related Products

No related products found.

Other Products

FAQs: HATU

Mainly as a peptide coupling reagent for forming amide bonds in solid-phase and solution-phase peptide synthesis, and more broadly as an acylation catalyst in organic synthesis.

Yes — it's classified Danger, a skin sensitizer (H317) and a respiratory sensitizer (H334), meaning repeated exposure can trigger allergic or asthma-like reactions; minimize inhalation and skin contact, especially with repeated handling.

C10H15F6N6OP, molecular weight 380.23 g/mol.

Refrigerated, at 2–8°C, per Sigma's reference data.

Yes, for every lot (SKU S3421).