Quote
Chemical structure of Ethyl 3,4-dihydroxybenzoate | 3943-89-3
CAS: 3943-89-3
SKU: S1521
Ethyl 3,4-dihydroxybenzoate | SKU: S1521
Synonyms: Ethyl protocatechuate; Protocatechuic acid ethyl ester; 3,4-Dihydroxybenzoic acid ethyl ester
Chemical structure of Ethyl 3,4-dihydroxybenzoate | 3943-89-3
Ethyl 3,4-dihydroxybenzoate (CAS 3943-89-3), also known as ethyl protocatechuate, is a crystalline phenolic ester supplied by Sarchem Labs for research, analytical, and specialty chemical applications. Structurally it is the ethyl ester of protocatechuic acid, pairing a catechol-type diphenol ring with an ester group, a combination that gives the molecule notable free-radical-scavenging behavior. Sarchem ships every lot with a Certificate of Analysis and Safety Data Sheet. The compound is most often selected as a research building block, an analytical reference material, and a subject of antioxidant/enzyme-inhibition studies.
Request Quote — S1521

Specifications

Melting Point133°C (lit. range 132–134°C)
ColorUndesignated
Formula Weight182.18
Physical FormCrystal-Powder at 20°C
Chemical Name or MaterialEthyl 3,4-Dihydroxybenzoate
Molecular FormulaC9H10O4
Molecular Weight182.18 g/mol (lit. 182.17)
SMILES StringCCOC(=O)c1ccc(O)c(O)c1
SolubilityInsoluble in water; soluble in ethanol and DMSO
CAS Number3943-89-3
NACRESNA.22
MDL NumberMFCD00002199
PubChem CID77547
Beilstein/REAXYS Number2097435
InChIKeyKBPUBCVJHFXPOC-UHFFFAOYSA-N
WGK Germany3

Applications

Antioxidant research (free-radical scavenger studies)
Prolyl 4-hydroxylase enzyme-inhibition studies (collagen/hypoxia-pathway research)
Organic synthesis building block
Antibacterial-activity screening
Cosmetic-ingredient antioxidant research
Analytical/HPLC reference material

Product Description

What is Ethyl 3,4-Dihydroxybenzoate?

Ethyl 3,4-dihydroxybenzoate is the ethyl ester of protocatechuic acid, a phenolic compound built on a catechol ring with a carboxylic ester group — commonly called ethyl protocatechuate in the literature. The two adjacent hydroxyl groups on its aromatic ring give it antioxidant character, letting it donate hydrogen atoms to neutralize reactive oxygen species.

Uses of Ethyl 3,4-Dihydroxybenzoate

Researchers use it as an antioxidant standard and synthetic building block for catechol derivatives, and as a probe compound in prolyl 4-hydroxylase enzyme-inhibition work tied to collagen formation and cellular oxygen sensing. It’s also evaluated in cosmetic formulation research and used as an HPLC reference/calibration standard.

Safety Information

  • GHS Pictogram: GHS07 (Warning)
  • Hazard Statements: H315, H319, H335
  • PPE: Safety goggles, nitrile gloves, lab coat, dust mask/respirator
  • Storage Class: 11 | WGK: 3

Related Products

No related products found.

Other Products

FAQs: Ethyl 3,4-dihydroxybenzoate

Mainly as a research-grade antioxidant standard and synthetic intermediate for catechol-based molecules; also used in prolyl-4-hydroxylase enzyme research and early-stage cosmetic testing.

Yes — same compound (CAS 3943-89-3), two naming conventions.

3943-89-3, corresponding to C9H10O4, MW ~182.18 g/mol.

GHS Warning-level irritant (H315/H319/H335) — gloves, eye protection, dust mask recommended.

~133°C, consistent with the independently reported 132–134°C literature range.