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Chemical structure of Dexmedetomidine | 113775-47-6
CAS: 113775-47-6
SKU: S3033
Dexmedetomidine | SKU: S3033
Synonyms: (S)-4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole; (+)-Medetomidine; Precedex (clinical brand reference only)
Chemical structure of Dexmedetomidine | 113775-47-6
Dexmedetomidine (CAS 113775-47-6) is a chiral imidazole compound supplied by Sarchem Labs as a research- and API-grade bulk chemical for laboratory and pharmaceutical development use only. It is the single S-enantiomer of medetomidine, pharmacologically a highly selective alpha-2 adrenergic receptor agonist. Every lot ships with a COA and SDS. This listing is not a finished pharmaceutical product; any clinical or veterinary use requires separately sourced, regulatory-approved material through licensed channels.
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Specifications

AppearanceWhite to off-white crystalline powder
Melting Point146–149°C
IUPAC Name5-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
Molecular FormulaC13H16N2
Molecular Weight200.28 g/mol
SolubilitySoluble in DMSO (>10 mM)
CAS Number113775-47-6
MDL NumberMFCD00880557
PubChem CID5311068
FDA UNII67VB76HONO
InChIKeyCUHVIMMYOGQXCV-NSHDSACASA-N
Isomeric SMILESCC1=C(C(=CC=C1)[C@H](C)C2=CN=CN2)C

Applications

HPLC/GC/LC-MS reference standard for method development
Alpha-2 adrenergic receptor binding/selectivity research
Preclinical pharmacology research (sedative/analgesic mechanism studies)
Process chemistry/synthetic route reference
Chiral resolution/stereochemistry research (S-enantiomer of medetomidine)

Product Description

What is Dexmedetomidine?

Dexmedetomidine is the single, pharmacologically active S-enantiomer of medetomidine, a synthetic imidazole known as a highly selective alpha-2 adrenergic receptor agonist. Under the brand Precedex it’s an FDA-approved sedative used clinically by licensed practitioners — but Sarchem Labs offers CAS 113775-47-6 strictly as a bulk research/analytical-grade chemical, not that finished drug product.

Uses of Dexmedetomidine

Used as an analytical reference standard for HPLC/LC-MS method development and identity/purity confirmation, and as a pharmacology tool compound to study alpha-2 receptor binding and signaling in vitro. Process chemists also reference it during route scouting or stereochemical comparison against racemic medetomidine.

Safety Information

  • Signal Word: Danger | GHS Pictograms: GHS07, GHS08
  • Hazard Statements: H317, H360, H373
  • PPE: Gloves, eye protection, protective clothing, fume hood; handle as a potent low-dose pharmacologically active substance even at small scale

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FAQs: Dexmedetomidine

As an analytical reference standard and alpha-2 adrenergic receptor pharmacology tool compound.

No — it's a research/analytical-grade bulk chemical. The FDA-approved clinical form (Precedex) is available only through licensed pharmaceutical channels.

113775-47-6, C13H16N2, MW ~200.28 g/mol.

Yes — GHS Danger: skin sensitization (H317), reproductive toxicity (H360), organ damage from repeated exposure (H373); also pharmacologically potent, handle with full PPE.

Dexmedetomidine is the single active S-enantiomer isolated from medetomidine, the racemic (mixed) form; the R-enantiomer contributes little receptor activity.