Cetrimide (CAS 8044-71-1) is a white to off-white quaternary ammonium compound and cationic surfactant with strong antimicrobial and antiseptic properties. It’s widely used as a disinfectant and antiseptic agent, and as a surfactant in pharmaceuticals, cosmetics, and laboratory applications. Its structure (C₁₇H₃₈BrN) helps reduce surface tension while targeting microbes, making it valuable in healthcare, personal care, and industrial formulations.
Synonym: Cetyltrimethylammonium bromide, CTAB, Cetavlon, Cetrimonium bromide, Hexadecyltrimethylammonium bromide, Trimethylcetylammonium bromide, N-Hexadecyltrimethylammonium bromide.
| Appearance | White to creamy-white, free-flowing crystalline powder |
| Melting Point | ≈ 245–250 °C |
| pH of Liquid, Typical (10% soln) | Approximately 4.5–6.5 (10% aqueous) |
| Specific Gravity Approx | bulk density ~0.35–0.55 g/mL typical for powder |
| Odor | Faint but characteristic, mild/soapy |
| Color | White to creamy-white |
| Linear Formula | [N⁺(C₁₄H₂₉)(CH₃)₃]Br⁻ |
| IUPAC Name | N,N,N-Trimethyltetradecylammonium bromide (quaternary ammonium salt) |
| Formula Weight | ≈ 336.39 g/mol |
| percent purity | Typically ≥ 99% |
| Physical Form | Solid powder (crystalline) |
| Chemical Name or Material | Cetrimide |
| Content / Assay Percent Range | 96.0 % – 101.0 % |
Classification of the substance or mixture
GHS Label elements, including precautionary statements
Hazards not otherwise classified (HNOC) or not covered by GHS
Yes
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS). For the full text of the H-Statements mentioned in this Section, see Section 16.
Yes
Signal word :
Warning
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Cetrimide is a quaternary ammonium compound with antiseptic and disinfectant properties. It works by disrupting microbial cell membranes, making it effective against bacteria, some fungi, and certain viruses in medical and hygiene applications.
Common cetrimide uses include wound cleansing, preoperative skin disinfection, and instrument sterilization. It is valued for its broad antimicrobial activity, making it a frequent choice in hospitals, clinics, and veterinary settings.
Cetrimide solution is typically diluted before use for wound irrigation, skin cleaning, or equipment sterilization. It provides effective antimicrobial action while minimizing tissue irritation when prepared at appropriate concentrations.
Possible cetrimide cream side effects include skin irritation, redness, itching, or allergic reactions in sensitive individuals. Discontinue use and seek medical advice if symptoms persist or worsen after application.
Yes, cetrimide is also applied in industrial and domestic cleaning products for its disinfectant properties. However, usage guidelines and concentrations should be followed to ensure safety and effectiveness in non-medical applications.
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