| Boiling Point | 73–75 °C at 15 mmHg (reduced pressure — see flag above; NOT confirmed as the atmospheric boiling point) |
| Density | 0.89 g/mL at 25 °C (lit.) |
| Flash Point | 70 °C, closed cup |
| Color | Yellow |
| Linear Formula | HC≡C(CH2)4OH |
| Quantity | 5mL |
| Formula Weight | 98.15 |
| percent purity | ≥95.0% (GC) |
| Physical Form | Clear liquid |
| Chemical Name or Material | 5-Hexyn-1-ol |
| Molecular Weight | 98.14–98.15 g/mol |
| SMILES String | `OCCCCC#C` |
| Beilstein | 1739774 |
| Refractive Index | n20/D 1.450 (lit.) |
| Assay | ≥95.0% (GC) (Sarchem spec) / 96% (Sigma reference) |
| CAS Number | 928-90-5 |
| Key Functional Groups | Hydroxyl |
| NACRES | NA.22 |
| PubChem Substance ID | 24858225 |
| UNSPSC Code | 12352100 |
| MDL Number | MFCD00002980 |
| Quality Segment | 100 |
| InChI | `1S/C6H10O/c1-2-3-4-5-6-7/h1,7H,3-6H2` |
| InChI Key | GOQJMMHTSOQIEI-UHFFFAOYSA-N |
5-Hexyn-1-ol is a six-carbon chain terminated at one end by a triple bond (a terminal alkyne) and at the other by a hydroxyl group, giving it two distinct and independently useful reactive sites. Terminal alkynes like this one are prized in modern organic synthesis for their compatibility with click chemistry (such as copper-catalyzed azide-alkyne cycloaddition) and metal-catalyzed cross-coupling reactions, while the primary alcohol provides a separate functional handle for esterification, oxidation, or protecting-group chemistry. Supplied by Sarchem Labs as a clear, yellow-tinted liquid, it serves as a compact, bifunctional building block for constructing more complex molecular architectures.
5-Hexyn-1-ol has been used as a key building block in total synthesis programs targeting complex natural products, including cinnoline-fused cyclic enediyne compounds and the lycopodium alkaloids (+)-nankakurine A and (+)-nankakurine B, where its terminal alkyne enables ring-forming and coupling steps central to these syntheses. It has also served as an intermediate in the preparation of 7-benzoyloxy-3-(2-nitrophenylseleno)-1,5-cyclodecadiyne. More broadly, its combination of a terminal alkyne and a primary alcohol makes it a versatile general-purpose building block wherever a short, bifunctional alkyne linker is needed in multi-step synthesis.
