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5-Fluoroisatin
CAS: 443-69-6
SKU: S1557
5-Fluoroisatin | SKU: S1557
Synonyms: 5-Fluoro-2,3-indoledione; NSC 39161
5-Fluoroisatin
5-Fluoroisatin is a fluorinated isatin that Sarchem Labs supplies as a solid — it is the documented precursor to sunitinib, an FDA-approved cancer drug. Every lot ships with a Certificate of Analysis and Safety Data Sheet.
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Specifications

Melting Point224–227°C
ColorUndesignated
Formula Weight165.12
Physical FormSolid
Chemical Name or Material5-Fluoroisatin
Molecular Weight165.12 g/mol
Assay97%
CAS Number443-69-6
Empirical FormulaC8H4FNO2
NACRESNA.22
PubChem Substance ID24862375
UNSPSC Code12352100
MDL NumberMFCD00022795
ApplicationsOncology drug manufacturing — 5-fluoroisatin is the documented precursor of sunitinib (Sutent), an FDA-approved drug (2006) for renal cell carcinoma and gastrointestinal stromal tumor

Applications

Oncology drug manufacturing — 5-fluoroisatin is the documented precursor of sunitinib (Sutent), an FDA-approved drug (2006) for renal cell carcinoma and gastrointestinal stromal tumor
Kinase-inhibitor drug research (c-Met kinase, TAK1 kinase, IKKβ inhibitor synthesis)
Antiviral and antimicrobial research (herpes simplex virus inhibitors, antimycobacterial and anti-HIV drug-candidate synthesis)

Product Description

What is 5-Fluoroisatin?

Isatin (indole-2,3-dione) is a privileged scaffold in medicinal chemistry, and its 5-fluoro derivative specifically is the documented starting material for sunitinib, a multi-target tyrosine kinase inhibitor. Isatins are also broadly used to build spirooxindole and Schiff-base pharmacophores across drug-discovery research.

Uses of 5-Fluoroisatin

This compound is manufactured into sunitinib, an approved targeted cancer therapy, and is used more broadly in kinase-inhibitor, antimicrobial, and antiviral drug-candidate research as a versatile isatin-scaffold building block.

Safety Information

  • Signal Word: Warning | Hazard Statements: H315 (Skin irritation), H319 (Eye irritation), H335 (Respiratory irritation)
  • Hazard Classification: Eye Irrit. 2, Skin Irrit. 2, STOT SE 3
  • PPE: Dust mask type N95 (US), eyeshields, gloves
  • Storage Class: 11 – Combustible Solids

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FAQs: 5-Fluoroisatin

Its most notable use is as the precursor to sunitinib, an FDA-approved kidney-cancer/GIST drug — it's also a versatile building block across kinase-inhibitor and antimicrobial drug research.

Yes, for every lot (SKU S1557).