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4,6-Dichloro-5-nitropyrimidine (CAS 4316-93-2) is a halogenated pyrimidine intermediate (≥98% purity) used in organic synthesis. It’s mainly applied in pharmaceutical and agrochemical research as a building block for active compounds and crop protection agents. This solid chemical has a molecular weight of ~194 g/mol and requires careful handling due to irritant properties.
Synonym:pyrimidine, 4,6-dichloro-5-nitro, 4,6-dichloro-5-nitro-pyrimidine, 4,6-dichloro-5-nitro-pyridine, pubchem7078, acmc-1an8c, 4-23-00-00899 beilstein handbook reference, ksc495i5h, 4,6-dichloro-5-nitroprimidine, 4,6 dichloro-5-nitropyrimidine, 5-nitro 4,6-dichloropyrimidine
| Appearance | White to off-white to pale yellow / pale brown crystalline solid |
| Melting Point | 100 – 103 °C (literature) |
| pH of Liquid, Typical (10% soln) | Not typically measured for this solid intermediate |
| Specific Gravity Approx | Approx. 1.7–1.74 g/cm³ |
| Odor | Slight chemical / typical organic nitro compound odor |
| Color | White to off-white to pale yellow / pale brown |
| Linear Formula | C₄HCl₂N₃O₂ |
| IUPAC Name | 4,6-Dichloro-5-nitropyrimidine |
| Formula Weight | 193.98 g/mol |
| percent purity | ≥ 98 % (HPLC / GC) |
| Physical Form | Crystalline solid / powder |
| Chemical Name or Material | 4,6-Dichloro-5-nitropyrimidine |
| Beilstein | 162029 |
| Content / Assay Percent Range | ≥ 98 % (HPLC / GC) |
Classification of the substance or mixture
GHS Label elements, including precautionary statements
Yes
Hazards not otherwise classified (HNOC) or not covered by GHS
Yes
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS). For the full text of the H-Statements mentioned in this Section, see Section 16.
Yes
Signal word :
Warning
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4,6-Dichloro-5-nitropyrimidine is a halogenated heterocyclic compound used as an intermediate in pharmaceutical and agrochemical synthesis. Its reactive chlorine and nitro groups make it valuable for creating complex organic molecules.
The compound contains two chlorine atoms and one nitro group on a pyrimidine ring. These substituents enhance its electrophilicity, enabling selective nucleophilic substitution reactions important in advanced synthetic pathways.
4,6-Dichloro-5-nitropyrimidine is usually produced by chlorination of nitropyrimidine derivatives under controlled conditions. The process is optimized to achieve high yields and purity for subsequent industrial or research applications.
It is widely used as a building block for pharmaceuticals, herbicides, and specialty chemicals. Its functional groups make it an essential intermediate for synthesizing biologically active heterocyclic compounds.
Yes, due to its chemical reactivity, handling requires protective gloves, goggles, and good ventilation. Avoid inhalation or skin contact, and follow standard laboratory safety protocols during storage and use.
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