| Appearance | Crystalline solid; white to beige/pink or brown powder/crystals |
| Melting Point | ~ 89 – 95 °C |
| pH of Liquid, Typical (10% soln) | Not routinely reported (aqueous pH not typically specified) |
| Specific Gravity Approx | ~ 1.85–2.0 g/cm³ (solid density) |
| Odor | Characteristic phenolic/organic odor (typical for phenols; not formally specified) |
| Color | White to beige/pink to brown (can vary with purity) |
| Linear Formula | IC₆H₄OH (or C₆H₄IOH) |
| IUPAC Name | 4-iodophenol |
| Formula Weight | ~ 220.01 g/mol |
| percent purity | ≥ 98 % (varies by grade) |
| Physical Form | Solid (crystals or powder) |
| Chemical Name or Material | 4-iodophenol (p-iodophenol, 4-hydroxyiodobenzene) |
| Content / Assay Percent Range | Typically ≥ 98 % |
| 10894 |
4-Iodophenol is an aromatic halogenated phenol used as an intermediate in organic and chemical synthesis. The presence of both an iodine substituent and a phenolic hydroxyl group makes it useful in coupling reactions, functional group transformations, and the preparation of speciality chemicals. It is commonly applied in research and industrial settings where iodinated aromatic compounds are required.
Synonym: p-iodophenol, phenol, 4-iodo, phenol, p-iodo, 4-hydroxyiodobenzene, p-hydroxyiodobenzene, 4-hydroxyphenyl iodide, 4-iodo-phenol, unii-bh194bak0b, ccris 668, bh194bak0b
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Iodophenol is a halogenated aromatic compound derived from phenol, containing one or more iodine atoms. It serves as an important intermediate in pharmaceuticals, dyes, and fine chemical synthesis due to its reactivity.
Iodophenol compounds are crystalline solids or liquids with moderate polarity, high molecular weight, and strong electron-withdrawing iodine substituents. They are slightly soluble in water and highly reactive in electrophilic and cross-coupling reactions.
There are three primary isomers of Iodophenol—ortho (2-Iodophenol), meta (3-Iodophenol), and para (4-Iodophenol). Each varies in reactivity and application based on the iodine's position on the phenol ring.
Iodophenol is widely used in organic synthesis, particularly in the preparation of aryl iodides, ligands, and bioactive molecules. It’s also important in cross-coupling reactions like Suzuki and Sonogashira.
Yes, Iodophenols are highly reactive in metal-catalyzed cross-coupling reactions due to the presence of the iodine atom. This makes them valuable intermediates in forming carbon-carbon and carbon-heteroatom bonds.