Chemical structure of 4-Iodophenol | 540-38-5
SKU: S1666

4-Iodophenol | 540-38-5 | Sarchem Labs

SKU: S1666

Description

10894

4-Iodophenol is an aromatic halogenated phenol used as an intermediate in organic and chemical synthesis. The presence of both an iodine substituent and a phenolic hydroxyl group makes it useful in coupling reactions, functional group transformations, and the preparation of speciality chemicals. It is commonly applied in research and industrial settings where iodinated aromatic compounds are required.

Synonym: p-iodophenol, phenol, 4-iodo, phenol, p-iodo, 4-hydroxyiodobenzene, p-hydroxyiodobenzene, 4-hydroxyphenyl iodide, 4-iodo-phenol, unii-bh194bak0b, ccris 668, bh194bak0b

 

SPECIFICATION

AppearanceCrystalline solid; white to beige/pink or brown powder/crystals
Melting Point~ 89 – 95 °C
pH of Liquid, Typical (10% soln)Not routinely reported (aqueous pH not typically specified)
Specific Gravity Approx~ 1.85–2.0 g/cm³ (solid density)
OdorCharacteristic phenolic/organic odor (typical for phenols; not formally specified)
ColorWhite to beige/pink to brown (can vary with purity)
Linear FormulaIC₆H₄OH (or C₆H₄IOH)
IUPAC Name4-iodophenol
Formula Weight~ 220.01 g/mol
percent purity≥ 98 % (varies by grade)
Physical FormSolid (crystals or powder)
Chemical Name or Material4-iodophenol (p-iodophenol, 4-hydroxyiodobenzene)
Content / Assay Percent RangeTypically ≥ 98 %

Safety Information

Classification of the substance or mixture

GHS Label elements, including precautionary statements

Hazards not otherwise classified (HNOC) or not covered by GHS

GHS Classification in accordance with 29 CFR 1910 (OSHA HCS). For the full text of the H-Statements mentioned in this Section, see Section 16.

Yes

Signal word :

Warning

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FAQs: 4-Iodophenol

Iodophenol is a halogenated aromatic compound derived from phenol, containing one or more iodine atoms. It serves as an important intermediate in pharmaceuticals, dyes, and fine chemical synthesis due to its reactivity.

Iodophenol compounds are crystalline solids or liquids with moderate polarity, high molecular weight, and strong electron-withdrawing iodine substituents. They are slightly soluble in water and highly reactive in electrophilic and cross-coupling reactions.

There are three primary isomers of Iodophenol—ortho (2-Iodophenol), meta (3-Iodophenol), and para (4-Iodophenol). Each varies in reactivity and application based on the iodine's position on the phenol ring.

Iodophenol is widely used in organic synthesis, particularly in the preparation of aryl iodides, ligands, and bioactive molecules. It’s also important in cross-coupling reactions like Suzuki and Sonogashira.

Yes, Iodophenols are highly reactive in metal-catalyzed cross-coupling reactions due to the presence of the iodine atom. This makes them valuable intermediates in forming carbon-carbon and carbon-heteroatom bonds.