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Chemical structure of 2-Chloro-5-hydroxypyridine | 41288-96-4
CAS: 41288-96-4
SKU: S2122
2-Chloro-5-hydroxypyridine | SKU: S2122
Synonyms: 6-Chloro-3-pyridinol; 6-Chloropyridin-3-ol
Chemical structure of 2-Chloro-5-hydroxypyridine | 41288-96-4
2-Chloro-5-hydroxypyridine (CAS 41288-96-4) is a chlorinated pyridinol building block supplied by Sarchem Labs for pharmaceutical and agrochemical synthesis. The molecule pairs a reactive chlorine at the 2-position with a hydroxyl at the 5-position, giving chemists two distinct reactive handles for substitution and cross-coupling chemistry. Every lot can be backed by a COA and SDS.
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Specifications

Melting Point159°C (existing Sarchem spec; ChemicalBook lists 155–158°C, flagged not resolved)
ColorUndesignated
IUPAC Name6-Chloropyridin-3-ol
Formula Weight129.54 g/mol
Physical FormCrystal-Powder at 20°C
Chemical Name or Material2-Chloro-5-hydroxypyridine
Molecular FormulaC5H4ClNO
SMILES StringC1=CC(=NC=C1O)Cl
CAS Number41288-96-4
EC Number670-289-1
MDL NumberMFCD00234050
PubChem CID819821
InChIKeyKVCOOWROABTXDJ-UHFFFAOYSA-N

Applications

Substituted pyridine/pyridinol building block for pharmaceutical R&D
Agrochemical/crop-protection intermediate synthesis
Nucleophilic aromatic substitution substrate (reactive C–Cl bond)
Palladium-catalyzed cross-coupling for heterocyclic libraries
Analytical reference compound

Product Description

What is 2-Chloro-5-hydroxypyridine?

2-Chloro-5-hydroxypyridine is a chlorinated pyridinol compound (C5H4ClNO) used as a chemical intermediate in pharmaceutical and agrochemical synthesis. Its chlorine and hydroxyl groups sit on different ring positions, letting chemists selectively functionalize one site while leaving the other available for a later step.

Uses of 2-Chloro-5-hydroxypyridine

Its C–Cl bond supports nucleophilic aromatic substitution, while the hydroxyl group can be derivatized or used in metal-catalyzed cross-coupling — useful for assembling heterocyclic structures in drug-discovery and crop-protection research. Also used as an analytical/method-development reference standard.

Safety Information

  • Signal Word: Warning | GHS Pictogram: GHS07
  • Hazard Statements: H315, H319, H335
  • PPE: Chemical-resistant gloves, goggles/face shield, respirator if dust generated

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FAQs: 2-Chloro-5-hydroxypyridine

Building substituted pyridine ring systems in pharmaceutical and agrochemical research via substitution/cross-coupling chemistry.

41288-96-4 — also known as 6-chloropyridin-3-ol.

GHS Warning — skin/eye/respiratory irritant (H315/H319/H335).

C5H4ClNO, MW 129.54 g/mol.

Room temperature, tightly sealed, ideally under inert atmosphere.