CAS: 399-94-0
SKU: S2045
2-Bromo-1,4-difluorobenzene | SKU: S2045
Synonyms: 1-Bromo-2,5-difluorobenzene
2-Bromo-1,4-difluorobenzene is a trihalogenated benzene that Sarchem Labs supplies as a liquid for pharmaceutical and agrochemical intermediate manufacturing. Every lot ships with a Certificate of Analysis and Safety Data Sheet.

Specifications

Boiling Point58–59°C at 20 mmHg
Melting Point−31°C (lit.)
Density1.708 g/mL at 25°C (lit.)
ColorYellow
Linear FormulaBrC6H3F2
Formula Weight192.99
Physical FormLiquid
Chemical Name or Material1-Bromo-2,5-difluorobenzene
Molecular Weight192.99 g/mol
Refractive Indexn20/D 1.508 (lit.)
Assay98%
CAS Number399-94-0
EC Number206-920-0
NACRESNA.22
PubChem Substance ID24854903
MDL NumberMFCD00000345

Applications

Pharmaceutical intermediate manufacturing (lithiation building block for anthraquinone-based synthesis, including precursors to ametantrone-class chemistry)
Agrochemical intermediate synthesis

Product Description

What is 2-Bromo-1,4-difluorobenzene?

This compound is a benzene ring carrying a bromine and two fluorine substituents. The bromine provides a metal-halogen exchange or cross-coupling handle, while the electron-withdrawing fluorines direct further functionalization — a combination widely used in pharmaceutical building-block chemistry.

Uses of 2-Bromo-1,4-difluorobenzene

This compound is used in pharmaceutical manufacturing as a lithiation substrate (via LDA or butyllithium) en route to difluoroanthraquinone intermediates, and more broadly as a halogenated building block in agrochemical synthesis.

Safety Information

  • Signal Word: Warning | Hazard Statements: H315 (Skin irritation), H319 (Eye irritation), H335 (Respiratory irritation)
  • Hazard Classification: Eye Irrit. 2, Skin Irrit. 2, STOT SE 3
  • PPE: Eyeshields, gloves, type ABEK (EN14387) respirator filter
  • Storage Class: 10 – Combustible liquids | Flash Point: 65°C (closed cup)

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FAQs: 2-Bromo-1,4-difluorobenzene

Mainly as a lithiation substrate and building block in pharmaceutical and agrochemical intermediate manufacturing.

Yes, for every lot (SKU S2045).