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Chemical structure of 1-Pyrenebutyric acid | 3443-45-6
CAS: 3443-45-6
SKU: S2081
1-Pyrenebutyric acid | SKU: S2081
Synonyms: 4-(1-Pyrenyl)butanoic acid, 4-(pyren-1-yl)butanoic acid
Chemical structure of 1-Pyrenebutyric acid | 3443-45-6
1-Pyrenebutyric acid (CAS 3443-45-6) is a pyrene-based fluorescent probe molecule that Sarchem Labs supplies as a high-purity yellow crystalline powder for use in fluorescence labeling and surface-functionalization research. It combines the strong, well-characterized fluorescence of the pyrene aromatic system with a terminal carboxylic acid group, giving researchers a convenient handle for attaching the fluorophore to surfaces, nanomaterials, or biomolecules via standard carboxylic-acid coupling chemistry. Sarchem Labs backs every lot with a Certificate of Analysis and Safety Data Sheet. It is used extensively in materials science and bioconjugation research wherever a robust, easily conjugated fluorescent tag is needed.
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Specifications

Boiling Point515.9 °C at 760 mmHg
Melting Point184–189 °C (marketplace reference: 184–186 °C; Sarchem's existing spec: 189 °C — minor variance, see note)
ColorYellow
Linear FormulaC20H16O2
Formula Weight288.35
percent purity95%
Physical FormSolid
Chemical Name or Material1-Pyrenebutyric Acid
Molecular Weight288.35 g/mol
CAS Number3443-45-6
Storage Temperature4 °C, protect from light
MDL NumberMFCD00004141
InChI`1S/C20H16O2/c21-18(22)6-2-3-13-7-8-16-10-9-14-4-1-5-15-11-12-17(13)20(16)19(14)15/h1,4-5,7-12H,2-3,6H2,(H,21,22)`
InChI KeyQXYRRCOJHNZVDJ-UHFFFAOYSA-N

Applications

Fluorescent probe for labeling nanomaterials and carbon-based surfaces (e.g., carbon nanotubes, graphene) via pi-stacking and carboxylic-acid coupling
Bioconjugation chemistry, linking the pyrene fluorophore to biomolecules through its carboxylic acid group
Fluorescence microscopy and spectroscopy research requiring a stable, strongly fluorescent tag
Polarity and micro-environment sensing in membrane and polymer studies, leveraging pyrene’s well-known solvatochromic fluorescence behavior

Product Description

What is 1-Pyrenebutyric Acid?

1-Pyrenebutyric acid is a fluorescent probe molecule consisting of a pyrene ring system connected to a four-carbon butanoic acid chain. Pyrene itself is prized in fluorescence research for its strong, long-lived fluorescence and sensitivity to its local chemical environment, and attaching a carboxylic acid tail via a flexible butyl linker gives chemists a practical way to couple this fluorophore onto other molecules or surfaces without disrupting its aromatic core. Supplied by Sarchem Labs as a 95%-pure yellow crystalline solid, it is a widely used building block in fluorescence-based research.

Uses of 1-Pyrenebutyric Acid

The defining use of 1-pyrenebutyric acid is as a fluorescent tag: its carboxylic acid group allows straightforward coupling to amines, alcohols, and other functional groups on biomolecules, polymers, and nanomaterials, while the pyrene core provides a strong, easily detected fluorescence signal. It is especially popular for functionalizing carbon-based nanomaterials such as carbon nanotubes and graphene, where the flat pyrene ring adsorbs onto the surface via pi-stacking interactions while the carboxylic acid remains available for further conjugation. It’s also used in membrane and polymer research, where pyrene’s fluorescence is sensitive to its surrounding polarity, making pyrenebutyric acid a useful reporter of local micro-environment changes.

Safety Information

No Safety Information Found

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FAQs: 1-Pyrenebutyric acid

It is used primarily as a fluorescent probe for labeling nanomaterials, biomolecules, and polymers, taking advantage of pyrene's strong fluorescence and the molecule's carboxylic acid group for easy chemical coupling.

Its flat, aromatic pyrene ring adsorbs onto carbon surfaces through pi-stacking interactions, while the carboxylic acid tail remains free for further chemistry — giving researchers a simple, non-covalent way to add functional handles to otherwise inert carbon nanomaterials.

It should be stored at 4 °C and protected from light, since light exposure can degrade its fluorescence performance over time.

The marketplace reference source lists 184–186 °C while Sarchem's own existing published spec lists 189 °C — these are reasonably close and may reflect normal batch-to-batch or measurement variance, but it's worth a quick cross-check against your own COA.

Sarchem Labs supplies this compound at 95% purity, with a Certificate of Analysis available for every lot.