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CAS: 552846-17-0
SKU: S3413
1-Boc-4-pyrazoleboronic acid pinacol ester | SKU: S3413
Synonyms: 1-Boc-pyrazole-4-boronic acid pinacol ester
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1-Boc-4-pyrazoleboronic Acid Pinacol Ester is a protected heterocyclic boronate that Sarchem Labs supplies as a white crystalline powder for pharmaceutical synthesis manufacturing. It’s a standard building block for introducing a pyrazole ring via Suzuki-Miyaura cross-coupling chemistry. Every lot ships with a Certificate of Analysis and Safety Data Sheet.
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Specifications

Melting Point86°C (per Sarchem's existing published data)
ColorWhite
Formula Weight294.16
Physical FormCrystal-powder
Chemical Name or Material1-(tert-Butoxycarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Molecular Weight294.16 g/mol
CAS Number552846-17-0
ApplicationsSuzuki-Miyaura cross-coupling reaction building block (pyrazole-ring installation)

Applications

Suzuki-Miyaura cross-coupling reaction building block (pyrazole-ring installation)
Pharmaceutical intermediate manufacturing (pyrazole-containing drug candidate synthesis)
Medicinal-chemistry building-block research

Product Description

What is 1-Boc-4-pyrazoleboronic Acid Pinacol Ester?

This compound combines a Boc-protected pyrazole ring with a pinacol boronate ester at the 4-position, giving it the reactivity profile needed for palladium-catalyzed Suzuki-Miyaura cross-coupling while the Boc group protects the pyrazole nitrogen during synthesis. This combination makes it a standard, shelf-stable reagent for introducing pyrazole rings into more complex target molecules.

Uses of 1-Boc-4-pyrazoleboronic Acid Pinacol Ester

This building block is used throughout pharmaceutical intermediate manufacturing wherever a pyrazole ring needs to be installed via cross-coupling — pyrazole-containing scaffolds appear in numerous drug candidates across therapeutic areas, making this a frequently used medicinal-chemistry reagent.

Safety Information

PPE: Standard laboratory precautions — gloves, eyeshields, dust mask

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FAQs: 1-Boc-4-pyrazoleboronic acid pinacol ester

Mainly as a building block for installing pyrazole rings into pharmaceutical intermediates via Suzuki-Miyaura cross-coupling chemistry.

It protects the pyrazole ring's nitrogen during synthesis and cross-coupling, and can be removed later under mild acidic conditions once the coupling step is complete.

294.16 g/mol.

Yes, for every lot (SKU S3413).