| Boiling Point | 178–180°C/0.5 mmHg (lit.) |
| Melting Point | 65–70°C (lit.) |
| Color | White |
| Formula Weight | 286.80 |
| Physical Form | Crystal-powder |
| Chemical Name or Material | 1-(4-Chlorobenzhydryl)piperazine |
| Molecular Weight | 286.80 g/mol |
| SMILES String | Clc1ccc(cc1)C(N2CCNCC2)c3ccccc3 |
| CAS Number | 303-26-4 |
| Storage Temperature | 2–30°C |
| Empirical Formula | C17H19ClN2 |
| NACRES | NA.24 |
| UNSPSC Code | 41116107 |
| MDL Number | MFCD00005965 |
| InChI | 1S/C17H19ClN2/c18-16-8-6-15(7-9-16)17(14-4-2-1-3-5-14)20-12-10-19-11-13-20/h1-9,17,19H,10-13H2 |
| InChI Key | UZKBSZSTDQSMDR-UHFFFAOYSA-N |
| Quality Level | 300 |
| API Family | Hydroxyzine (related-compound reference) |
| Applications | Antihistamine drug manufacturing (impurity/related-compound reference standard for cetirizine, hydroxyzine, and meclizine) |
This compound combines a piperazine ring with a 4-chlorobenzhydryl (chlorinated diphenylmethyl) group — the core structural fragment shared by an entire family of first-generation antihistamine drugs, including chlorcyclizine and its downstream derivatives hydroxyzine, cetirizine, and meclizine. As the “nor” (des-alkyl) parent structure, it appears both as a synthesis intermediate and as a specified impurity/degradation marker in the quality control of these finished drugs.
This compound is used as a pharmaceutical intermediate in antihistamine synthesis and, equally importantly, as a certified reference standard for identifying and quantifying this specific impurity in finished hydroxyzine, cetirizine, and meclizine drug products during pharmaceutical manufacturing quality control.
Sigma Aldrich’s GHS classification includes a suspected reproductive-toxicity warning — Sarchem’s live page currently has zero safety information for this product.
