CAS: 6381-91-5
SKU: S3393
Calcium Saccharin | SKU: S3393
Synonyms: Saccharin hemicalcium salt; 2,3-Dihydro-3-oxobenzisosulfonazole; o-Sulfobenzimide
Calcium Saccharin is the calcium salt of saccharin, a high-intensity non-nutritive sweetener valued for delivering a strong sweet taste at very low use levels without contributing meaningful calories. Its defining feature is the calcium counterion in place of sodium, which makes it a useful substitute wherever a formulation needs saccharin’s sweetening power but a reduced sodium load. Sarchem Labs supplies Calcium Saccharin (CAS 6381-91-5) as a stable, water-soluble solid, with a Certificate of Analysis and Safety Data Sheet issued with every order. Typical uses span food and beverage sweetening systems, dietetic and reduced-sugar product lines, and pharmaceutical formulations where a low-sodium sweetening agent is preferred.

Specifications

Flash PointNot applicable
Physical FormWhite crystalline powder
Molecular FormulaC₁₄H₈CaN₂O₆S₂ · 3.5H₂O
Molecular Weight467.48 g/mol
CAS Number6381-91-5
NACRESNA.24
UNSPSC Code41116107
MDL NumberMFCD24691681
InChI1S/2C7H5NO3S.Ca.H2O/c2*9-7-5-3-1-2-4-6(5)12(10,11)8-7;;/h2*1-4H,(H,8,9,10,11);;1H2/q;;+2;/p-2
InChI KeyXOCXGVIOTKFUSU-UHFFFAOYSA-L

Applications

Non-nutritive, high-intensity sweetener in food and beverage formulations
Sugar-replacement ingredient in pharmaceutical dosage forms (chewable tablets, oral suspensions, syrups, effervescent products) where a lower-sodium alternative to sodium saccharin is preferred
Tabletop sweetener blends and dietetic/reduced-sugar food products
Combination ingredient with other high-intensity sweeteners to balance overall sweetness profile

Product Description

What is Calcium Saccharin?

Calcium Saccharin is formed by neutralizing saccharin with a calcium base, producing the calcium salt in place of the far more common sodium version. It is generally isolated as a hydrate, giving the formula C₁₄H₈CaN₂O₆S₂·3.5H₂O and a molecular weight of about 467.48 g/mol, and presents as a white, water-soluble crystalline solid. The sweetness comes from the same imide-sulfonyl ring system found in all saccharin salts; the compound is not broken down metabolically, so it contributes essentially no calories.

Because it substitutes calcium for sodium, Calcium Saccharin is the salt of choice whenever a formulator needs saccharin’s sweetening effect but wants to avoid adding to a product’s sodium content.

Uses of Calcium Saccharin

Calcium Saccharin functions primarily as a sugar-replacement sweetener across food, beverage, and pharmaceutical applications where a low-calorie or reduced-sodium profile matters. It shows up in tabletop sweetener blends, diet beverages, and reduced-sugar food products, often paired with other high-intensity sweeteners.

In pharmaceutical manufacturing, it is used as a sweetening and taste-masking agent in chewable tablets, oral suspensions, syrups, and effervescent formulations — particularly for patients who need to limit sodium intake.

Safety Information

  •       Pictogram: GHS07 (exclamation mark)
  •       Signal Word: Warning
  •       Hazard Statements: H302+H312+H332 — Harmful if swallowed, in contact with skin, or if inhaled
  •       Precautionary Statements: P261, P280 (wear protective gloves/protective clothing/eye protection/face protection), P301+P312+P330
  •       Hazard Classifications: Acute Tox. 4 (Oral), Acute Tox. 4 (Dermal), Acute Tox. 4 (Inhalation)
  •       Storage Class: 11 — Combustible Solids
  •       Water Hazard Class (WGK): 3 — Severely hazardous to water
  •       Flash Point: Not applicable

Recommended PPE: Chemical-resistant gloves and eye/face protection should be worn when handling. Avoid generating or inhaling dust. Store in a tightly closed container in a cool, dry area away from incompatible materials.

Related Products

FAQs: Calcium Saccharin

Both are salts of the same sweetening compound, saccharin, but use different counterions. Calcium Saccharin is generally chosen when a formulation needs to minimize sodium content while still delivering saccharin's sweetness.

Like other saccharin salts, it is a high-intensity sweetener, delivering substantially more sweetness than an equivalent amount of sucrose while contributing essentially no calories.

Keep in a tightly sealed container in a cool, dry location, away from moisture given that it is typically supplied as a hydrate. Gloves and eye protection are recommended, and dust generation should be minimized since it is classified Acute Tox. 4 across all three exposure routes.

C₁₄H₈CaN₂O₆S₂·3.5H₂O, MW ≈ 467.48 g/mol, reflecting a single calcium ion bridging two saccharinate anions plus water of hydration. InChI Key XOCXGVIOTKFUSU-UHFFFAOYSA-L can be used to cross-reference the compound across databases.

Sarchem's S3393 is offered as a bulk commercial-grade chemical rather than a certified pharmacopeial reference standard. Customers who require a specific certification or compendial standard should contact Sarchem directly to confirm the current specification and COA.