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CAS: 74489-49-9
SKU: S3254
1-Azido-4-(bromomethyl)benzene | SKU: S3254
Synonyms: 4-Azidobenzyl bromide
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1-Azido-4-(bromomethyl)benzene (4-Azidobenzyl Bromide) is a bifunctional azide/bromide building block that Sarchem Labs supplies for pharmaceutical and bioconjugation manufacturing. Every lot ships with a Certificate of Analysis and Safety Data Sheet.
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Specifications

Molecular FormulaC7H6BrN3
Molecular Weight212.05 g/mol
CAS Number74489-49-9
ApplicationsClick chemistry and bioconjugation manufacturing — the azide group is the standard handle for copper-catalyzed azide-alkyne cycloaddition (CuAAC/"click") reactions, widely used in modern bioconjugation, PROTAC, and antibody-drug-conjugate (ADC) manufacturing

Applications

Click chemistry and bioconjugation manufacturing — the azide group is the standard handle for copper-catalyzed azide-alkyne cycloaddition (CuAAC/”click”) reactions, widely used in modern bioconjugation, PROTAC, and antibody-drug-conjugate (ADC) manufacturing
Pharmaceutical intermediate synthesis (the benzylic bromide provides a second, independent alkylation handle)

Product Description

What is 4-Azidobenzyl Bromide?

This compound combines an aryl azide with a reactive benzylic bromide on the same small molecule, giving two independently addressable functional handles: the azide for click chemistry, and the bromide for standard alkylation reactions. This bifunctionality makes it a useful linker-synthesis building block.

Uses of 4-Azidobenzyl Bromide

This compound is used as a bifunctional building block in click-chemistry and bioconjugation manufacturing, where the azide participates in CuAAC “click” cycloadditions (increasingly important in PROTAC and antibody-drug-conjugate manufacturing) while the benzylic bromide handles conventional alkylation chemistry.

Safety Information

· PPE: Fume hood recommended; eyeshields, gloves, standard azide-handling precautions

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FAQs: 1-Azido-4-(bromomethyl)benzene

Mainly as a bifunctional building block in click chemistry and bioconjugation manufacturing (PROTACs, antibody-drug conjugates).

Organic azides as a class can be thermally and shock-sensitive, particularly when concentrated or heated — standard azide-safety precautions should be followed regardless of the specific hazard classification on file.

C7H6BrN3, molecular weight 212.05 g/mol.

Yes, for every lot (SKU S3254).